CocoaDev

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FreeNode is the project formerly known as OpenProjects. They host an IRC service (irc.freenode.net), and there is a mac programmer’s channel #macdev. Undernet (irc.undernet.org) also has a mac channel (#macintosh), where some IRCers hang out in.

Undernet also has #macusers, which has a fair number of regulars, but which doesn’t often have dev stuff.